Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease.

In this study, we determined the roles of PEP-1-FK506BP on cell proliferation and cyst formation in PKD cells. Purified PEP-1-FK506BP transduced into PKD cells and markedly inhibited cell proliferation. Also, PEP-1-FK506BP drastically inhibited the expression levels of p-Akt, p-p70S6K, p-mTOR, and p-ERK in PKD cells. In a 3D culture system, PEP-1-FK506BP significantly reduced cyst formation. Furthermore, the combined effects of rapamycin and PEP-1-FK506BP on cyst formation were markedly higher than those of individual treatments. These results suggest that the PEP-1-FK506BP delays cyst formation and could be a new therapeutic strategy for renal cyst formation in PKD.
PMID: 28760196 [PubMed - as supplied by publisher]

Source: BMB Reports - July 28, 2017 Category: Biochemistry Authors: Jo HS, Eum WS, Park EY, Ko JY, Kim DY, Kim DW, Shin MJ, Son O, Cho SB, Park JH, Lee CH, Yeo EJ, Yeo HJ, Choi YJ, Youn JK, Cho SW, Park J, Park JH, Choi SY Tags: BMB Rep Source Type: research