Lost in Translation: No Effect of a High ‐Profile Publication on the Concomitant Use of Interacting Drugs

We examined prepublication and postpublication dispensing trends using Poisson regression. ACEI + potassium‐sparing diuretic use did not differ postpublication vs. prepublication (P = 0.11). Digoxin + clarithromycin use decreased minimally postpublication vs. prepublication (relative rate = 0.9996: 95% confidence interval [CI] = 0.9993–0.9998). Glyburide + cotrimoxazole use increased minimally postpublication vs. prepublication (relative rate = 1.0220; 95% CI = 1.0187–1.0254). Therefore, the high‐profile DDI publication had minimal to no measurable effect in reducing the concomitant use of the interacting drugs studied. We believe that better strategies are needed to translate knowledge about DDIs into clinical practice.
Source: Clinical and Translational Science - Category: Biomedical Science Authors: Tags: BRIEF REPORT Source Type: research