Psoriasis: a mixed autoimmune and autoinflammatory disease.

Psoriasis: a mixed autoimmune and autoinflammatory disease.
Curr Opin Immunol. 2017 Jul 21;49:1-8
Authors: Liang Y, Sarkar MK, Tsoi LC, Gudjonsson JE
Abstract
In recent years marked progress has been made in our understanding of the critical biologic and immunologic pathways involved in psoriasis. Genetic studies have demonstrated that susceptibility to psoriasis involves components of both the adaptive and innate immune system and not surprisingly activation of both of these arms of the immune system is found in psoriatic skin. While adaptive immune responses predominate in chronic plaque psoriasis, innate and autoinflammatory responses dominate in pustular forms of psoriasis, with other clinical subtypes extending on a spectrum between plaque and pustular psoriasis. This makes psoriasis a unique disease where both autoimmune and autoinflammatory responses co-exist, with the balance between the two being critical in shaping its clinical presentation.
PMID: 28738209 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - July 21, 2017 Category: Allergy & Immunology Authors: Liang Y, Sarkar MK, Tsoi LC, Gudjonsson JE Tags: Curr Opin Immunol Source Type: research