Quantitative reassessment of safety limits of tDCS for two animal studies

We read the article by Jackson et al. [1] with great interest. The authors concluded that the threshold for causing a brain lesion in a rat model using transcranial direct current stimulation (tDCS) is well below the level previously reported by Liebetanz et al. [2] Using a computational modeling approach, they also indicated that current density at the level of the brain is a better predictor of brain damage than current density at the level of electrode or electrode-skin interface. While we admire their scientific rigor and the use of computational modeling, we are concerned that the units of tDCS dose they chose has affected the relevance of the conclusions in the paper.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 24, 2017 Category: Neurology Authors: Pratik Y. Chhatbar, Mark S. George, Steven A. Kautz, Wuwei Feng Source Type: research