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Association of isotretinoin with depression and suicide: a review of current literature - Oliveira JM, Sobreira G, Velosa J, Telles Correia D, Filipe P.

Acne vulgaris, a condition that can affect people at any age, is the most common cause of referral to a dermatologist. Isotretinoin (ITT) is the most effective treatment available, but serious adverse effects, including a possible association with depressi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

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ConclusionMore than a half of the patients with acne who participated at the study had comorbid emotional disorders. Anxiety was the most prevalent sign, 1.7‐fold more prevalent than depression and 3‐fold more prevalent than suicidal ideation. Depression was prevalent in more than every fourth responder and suicidal ideation afflicted every eighth acne patient. More than 90% of the patients had impaired life quality.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Charlotte Carpenter, 24, from Burton-on-Trent, went to A&E with agonising pain and struggling to breathe after taking the acne drug - also linked to suicide - for just two months.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Charlotte Carpenter, 24, from Burton-on-Trent, went to A&E with agonising pain and struggling to breathe after taking the acne drug - also linked to suicide - for just two months.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Campaigners fear too many young people are being put on Roaccutane, a drug linked with suicidal feelings.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
An assessment of suicidal behaviors in the dermatology patient may be necessary in several situations: (1) in the presence of psychiatric comorbidity (major depressive disorder, body dysmorphic disorder, substance use disorder, posttraumatic stress disorder), encountered in up to 30% of dermatology patients; (2) when dermatologic symptoms ( “dysmorphophobia,” dermatitis artefacta) represent psychiatric pathologic conditions; (3) when psychosocial stressors (bereavement, interpersonal violence) increase the risk of suicidal behavior and exacerbate stress-reactive dermatoses (psoriasis, acne); (4) in the presence...
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research
Authors: Cooper AJ, Harris VR Abstract Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects. Depression, social isolation and suicidal id...
Source: Medical Journal of Australia - Category: Journals (General) Tags: Med J Aust Source Type: research
Conclusion: Patients with chronic dermatologic diseases are at high risk of developing psychological problems which may continue even after improvement of skin disease. The associated psychiatric disorders can range from short episodes of depression to major depression, anxiety, obsessive–compulsive disorders, and sleep disorders and can even extend to suicidal ideation and suicidal attempts. Management of the interaction between the mind and the skin can help to improve patients’ skin conditions and eventually their quality of life.
Source: Journal of the Egyptian Womens Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research
Date:   August 1, 2016 Issue #:   1500 Summary:   Our article earlier this year on Drugs for Acne 1 stated that the oral retinoid isotretinoin ( Accutane , and others) is the most effective drug available for patients with severe nodulocystic acne, but warned that depression, suicidality, myalgia, hypertriglyceridemia, and other adverse effects can occur. One of our readers objected to our listing depression and suicidality, which are the subject of a prominent warning in the package insert, in the same sentence as indisputable side effects such as hyperlipidemia and m...
Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Tags: Accutane Acne Isotretinoin Retinoids Source Type: research
Isotretinoin is used to treat severe and recalcitrant acne. Possible side effects include depression, suicide, and suicidal ideation; however, other studies suggest isotretinoin may improve mood and quality of life. Although iPLEDGE consenting warns about...
Source: SafetyLit - Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Isotretinoin is used to treat severe and recalcitrant acne. Possible side effects include depression, suicide, and suicidal ideation; however, other studies suggest isotretinoin may improve mood and quality of life. Although iPLEDGE consenting warns about the risk of depression and suicidal ideation, there is no recommendation for screening tools. The patient health questionnaire-2 and the patient health questionnaire-9 are validated instruments that enable dermatologists to efficiently screen for depression before and after isotretinoin is initiated.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
More News: Absorica | Accutane | Acne | Depression | Dermatology | International Medicine & Public Health | Skin | Suicide