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Association of isotretinoin with depression and suicide: a review of current literature - Oliveira JM, Sobreira G, Velosa J, Telles Correia D, Filipe P.

Acne vulgaris, a condition that can affect people at any age, is the most common cause of referral to a dermatologist. Isotretinoin (ITT) is the most effective treatment available, but serious adverse effects, including a possible association with depressi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

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Authors: Sabat R, Tsaousi A, Rossbacher J, Kurzen H, Fadai T, Schwichtenberg U, Schneider-Burrus S, Kokolakis G, Wolk K Abstract Acne inversa (AI)/hidradenitis suppurativa is a chronic, recurrent, immune-mediated dermatosis characterized by deep inflammatory nodules, abscesses, fistulas, and undermined scars in skin areas bearing apocrine glands. In addition to the cutaneous manifestation, numerous AI patients show metabolic changes, spondyloarthritis, and depression. AI leads to a strong reduction in the quality of life and an impairment of the sexual life of affected individuals and often culminates in ...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Summary Isotretinoin is used in the treatment of severe acne vulgaris (AV), but has controversially been associated with depression and suicide. Large prospective studies have failed to translate this clinically. We undertook a feasibility study to investigate the parameters of a triple‐blind, randomized controlled trial (RCT) assessing the effect of oral isotretinoin on quality of life (QoL) and mood in patients with AV. Patients meeting the inclusion criteria were randomized for 2 weeks to isotretinoin or doxycycline. Participants completed verified depression and QoL screening questionnaires at baseline and week...
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Concise report Source Type: research
This study assesses the impact of sexual orientation on the relationship between acne and mental health.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
ConclusionMore than a half of the patients with acne who participated at the study had comorbid emotional disorders. Anxiety was the most prevalent sign, 1.7‐fold more prevalent than depression and 3‐fold more prevalent than suicidal ideation. Depression was prevalent in more than every fourth responder and suicidal ideation afflicted every eighth acne patient. More than 90% of the patients had impaired life quality.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Charlotte Carpenter, 24, from Burton-on-Trent, went to A&E with agonising pain and struggling to breathe after taking the acne drug - also linked to suicide - for just two months.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Charlotte Carpenter, 24, from Burton-on-Trent, went to A&E with agonising pain and struggling to breathe after taking the acne drug - also linked to suicide - for just two months.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Campaigners fear too many young people are being put on Roaccutane, a drug linked with suicidal feelings.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
An assessment of suicidal behaviors in the dermatology patient may be necessary in several situations: (1) in the presence of psychiatric comorbidity (major depressive disorder, body dysmorphic disorder, substance use disorder, posttraumatic stress disorder), encountered in up to 30% of dermatology patients; (2) when dermatologic symptoms ( “dysmorphophobia,” dermatitis artefacta) represent psychiatric pathologic conditions; (3) when psychosocial stressors (bereavement, interpersonal violence) increase the risk of suicidal behavior and exacerbate stress-reactive dermatoses (psoriasis, acne); (4) in the presence...
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research
Authors: Cooper AJ, Harris VR Abstract Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects. Depression, social isolation and suicidal id...
Source: Medical Journal of Australia - Category: Journals (General) Tags: Med J Aust Source Type: research
Conclusion: Patients with chronic dermatologic diseases are at high risk of developing psychological problems which may continue even after improvement of skin disease. The associated psychiatric disorders can range from short episodes of depression to major depression, anxiety, obsessive–compulsive disorders, and sleep disorders and can even extend to suicidal ideation and suicidal attempts. Management of the interaction between the mind and the skin can help to improve patients’ skin conditions and eventually their quality of life.
Source: Journal of the Egyptian Womens Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research
More News: Absorica | Accutane | Acne | Depression | Dermatology | International Medicine & Public Health | Skin | Suicide