Primary calvarial tuberculosis.

CONCLUSION: Tuberculosis should be included in the differential diagnosis of the osteolytic lesions of skull with discharging sinus. A high degree of suspicion, especially in patients from low socioeconomic status, is warranted in managing such cases. PMID: 28713630 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

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In this study we analysed the clinical profile of meningoencephalitis and its clinical outcome. METHODS: Fifty adults diagnosed with meningoencephalitis from July 2014 to July 2015 in a tertiary care hospital in South India were studied prospectively and their clinical presentation, aetiology and outcome were analysed. RESULTS: Among 50 patients, 33 (66%) were male; 39 (78%) were
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Relevance: Genetics of widespread human diseases is a branch of research which is actively developing. The study of polymorphisms of known candidate genes and their prognostic impact on the disease, is one of the important tasks in the study of tuberculosis.Objective: To prevent the development of adverse reactions due to pharmacotherapy in multi-drug resistant tuberculosis considering deletion polymorphism of the genes in the detoxification system of glutathione-S-transferase xenobiotics.Subject: We have examined 100 patients with newly diagnosed multidrug-resistant uberculosis (MDR-TB).Methods: Polymorphism GSTM1 and GST...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Background: Drug resistance tuberculosis is a global health problem. Many countries are using Bedaquiline for the treatment of XDR-tuberculosis.Aim of the study: Comparing the frequency of adverse events (AE) on XDR-tuberculosis patients with a standard and prolonged course of treatment.Methods: Prospective study from 2012 to 2018. 148 patients diagnosed with XDR-tuberculosis pulmonary were treated with Bedaquiline. 28 patients had bilateral destruction in the lungs, prolonged bacterial excretion, a prolonged course was applied to them Bedaquiline 44-48 weeks (group 1). 120 patients received a standard (24 weeks) course Be...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
ConclusionsIdiopathic granulomatous hypophysitis, a rare inflammatory disease of the pituitary gland, is a diagnosis of exclusion for which both medical and surgical management are reported in the literature. We present a case of idiopathic granulomatous hypophysitis who was symptom free with no complications of hypopituitarism following its transsphenoidal resection after 9  months of follow-up.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
We describe demographic, socioeconomic and clinical characteristics of patients randomized to the same-day initiation arm for both studies. RESULTS AND DISCUSSION: A total of 240 and 296 participants were enrolled in Kenya and South Africa. The majority were female (59% and 64% respectively), with a median age of 35 years. In both countries, most subjects were newly diagnosed with HIV on the day of enrolment (62%, 55%), believed they already had adequate knowledge to begin ART (78%, 68%), and preferred to start ART immediately (same-day) (98% in both countries). About 40% of all patients had at least one symptom r...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Conclusion: The M72/AS01E vaccine against TB is safe and effective. Although the vaccine is associated with a mild adverse reaction, it is promising for the prevention of TB in healthy adults. Keywords: vaccine, tuberculosis, M72/AS01E, immunogenicity, safety
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We present a case that was initially suspected as tuberculous meningitis, but later diagnosed as central nervous system metastasis of NKTL, nasal type, which has never been published previously. Patient concerns: A 55-year-old Chinese man presented with persistent headache and fever. The initial head computed tomography and magnetic resonance imaging (MRI) scan was normal. Low glucose, elevated protein, and pleocytosis of cerebral spinal fluid led to a diagnosis of tuberculous meningitis. The patient did not respond to anti-tuberculosis treatment, and his symptoms aggravated. MRI showed abnormal lesions in the right hem...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
CONCLUSIONS: A high index of suspicion for IFG should exist for patients with an immunocompromised status and diabetic patients with rhinocerebral mass lesions. Early diagnosis, aggressive surgical decompression, and a course of promptly initiated antifungal therapy are associated with a better prognosis. PMID: 31370017 [PubMed - in process]
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSIONS: In our real-life analysis apremilast was mainly used in oligoarticular PsA carrying comorbidities leading to contraindications to biologics. Effectiveness and safety profiles were consistent with clinical trials. PMID: 31074721 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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