Vaccines for the Prevention of Melioidosis and Glanders

AbstractPurpose of ReviewBurkholderia pseudomallei’s andBurkholderia mallei’s high rate of infectivity, limited treatment options, and potential use as biological warfare agents underscore the need for development of effective vaccines against these bacteria. Research efforts focused on vaccines against these bacteria are in preclinical stages, with no approved formulati ons currently on the market.Recent FindingsSeveral live attenuated and subunit vaccine formulations have been evaluated in animal studies, with no reports of significant long-term survival after lethal challenge.SummaryThis review encompasses the most current vaccine strategies to preventB. pseudomallei andB. mallei infections while providing insight for successful vaccines moving forward.
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research