CD101, a long-acting echinocandin, and comparator antifungal agents tested against a global collection of invasive fungal isolates in the SENTRY 2015 antifungal surveillance program

• CD101 is a novel echinocandin with an extended half-life and can be dosed once a week• The activity of CD101 and comparators was evaluated using CLSI broth microdilution methods• A total of 713 invasive fungal isolates collected worldwide during 2015 were evaluated• CD101 activity was comp arable to that of other echinocandins against Candida spp. and Aspergillus spp.• FKS HS-mutant Candida spp. and Cryptococcus spp. displayed elevated CD101 and echinocandin MICs• CD101 will be a valuable addition to treatment options for invasive fungal infections
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research