Effects of siRNA targeting BMPR-II on the biological activities of human liver cancer cells and its mechanism

Conclusions: siRNA targeting BMPR-IIcan markedly inhibit HepG2 proliferation and invasion, promote apoptosis and block HepG2 in S phase. Its mechanism may be that BMPR-II silence down-regulates VEGF-C expression through MAPK/P38 and MAPK/ERK1/2 pathways, especially MAPK/P38. This study provides a new targeted therapy for liver cancer.
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Source Type: research