Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease

Conclusions:
In particular, CSF pNfH concentrations show an added value as diagnostic biomarkers for ALS, whereas the prognostic value of pNfH and NfL warrants further investigation. Both pNfH and NfL correlated with the extent of motor neuron degeneration.

Classification of evidence:
This study provides Class II evidence that elevated concentrations of CSF pNfH and NfL can accurately identify patients with ALS.

Source: Neurology - June 12, 2017 Category: Neurology Authors: Poesen, K., De Schaepdryver, M., Stubendorff, B., Gille, B., Muckova, P., Wendler, S., Prell, T., Ringer, T. M., Rhode, H., Stevens, O., Claeys, K. G., Couwelier, G., D'Hondt, A., Lamaire, N., Tilkin, P., Van Reijen, D., Gourmaud, S., Fedtke, N., Heiling, Tags: Amyotrophic lateral sclerosis, Cerebrospinal Fluid ARTICLE Source Type: research