Pyramidal tract activation due to subthalamic deep brain stimulation in Parkinson's disease

ConclusionsDirect pyramidal tract activation can occur at stimulation thresholds that are within the range used in clinical routine. This spread of current compromises increase in stimulation strengths and is related to the development of side effects such as speech disturbances with chronic stimulation. © 2017 International Parkinson and Movement Disorder Society
Source: Movement Disorders - Category: Neurology Authors: Tags: Research Article Source Type: research

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Corrigendum to "Five-Year Clinical Outcomes of Local versus General Anesthesia Deep Brain Stimulation for Parkinson's Disease". Parkinsons Dis. 2019;2019:2654204 Authors: Tsai ST, Chen TY, Lin SH, Chen SY Abstract [This corrects the article DOI: 10.1155/2019/5676345.]. PMID: 31827761 [PubMed - in process]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
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Source: British Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
This report provides concrete evidence that wheezing is caused by hyperadduction of the false vocal fold as an adverse effect of STN-DBS and can be reversed by adjusting the stimulation site for STN-DBS.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionThe surgical and clinical outcomes of asleep DBS for PD are comparable to those of awake DBS.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Review Article Source Type: research
ConclusionIntraoperative testing reliably predicts postoperative thresholds. These results are relevant during the informed consent process and patient counseling for DBS surgery. These will also guide the development of future methods for intraoperative feedback, especially during asleep DBS.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Clinical Research Source Type: research
ConclusionsStimulation of STN at 80 Hz and 130 Hz may have different effects on proximal and distal muscle control. One hundred and thirty Hertz may have a small advantage for distal hand muscles, whereas 80 Hz is more effective in improving proximal muscle function.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Deep brain stimulation (DBS) is the most successful surgical procedure for the treatment of advanced Parkinson's disease (PD) patients [1] when certain cardinal symptoms are insufficiently controlled with medications and medication-induced motor complications emerge. It has become the most significant treatment option for PD after levodopa. There is clear evidence of its superiority over continued best medical management of cardinal PD motor symptoms, motor complications, and overall quality of life in carefully selected PD patients [2 –4].
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Deep brain stimulation (DBS) is the most successful surgical procedure for the treatment of advanced Parkinson ’s disease (PD) patients [1] when certain cardinal symptoms are insufficiently controlled with medications resulting in motor complications including excessive off time and dyskinesias. It has become the most significant treatment option for PD after levodopa. There is clear evidence of DBS superi ority over continued best medical management of cardinal PD motor symptoms, motor complications, and overall quality of life in carefully selected PD patients [2-4].
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Editorial Source Type: research
Condition:   Parkinson Disease Intervention:   Device: Deep Brain Stimulation Sponsors:   Northwell Health;   National Institute of Neurological Disorders and Stroke (NINDS);   The University of Tennessee, Knoxville Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsTogether, these results demonstrate the importance of personalized targeting and validate a set of microelectrode recording signatures to predict therapeutic activation volumes. These features may be used to improve the efficiency of deep brain stimulation programming and highlight specific neural oscillations of physiological importance.
Source: Brain Stimulation - Category: Neurology Source Type: research
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