Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis [Medical Sciences]

The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling...

http://www.pnas.org/content/114/22/E4462.short?rss=1

Source: Proceedings of the National Academy of Sciences - May 30, 2017 Category: Science Authors: Brian T. D. Tobe, Andrew M. Crain, Alicia M. Winquist, Barbara Calabrese, Hiroko Makihara, Wen-ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D. Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steve Tags: PNAS Plus Source Type: research