Effect of N ‐acetylcysteine on motivation, seeking and relapse to ethanol self‐administration

We report here N‐acetylcysteine (NAC) efficacy to reduce operant ethanol self‐administration in rats during short‐time session of 15 minutes. NAC also reduces seeking and reacquisition following protracted abstinence. Our results suggest for the first time that NAC is a potential new anticraving treatment for reduction of alcohol relapse.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fadb.12521

Source: Addiction Biology - May 1, 2017 Category: Addiction Authors: Sophie Lebourgeois, Mar ía Carmen González‐Marín, Jerome Jeanblanc, Mickael Naassila, Catherine Vilpoux Tags: Original Article Source Type: research