Mesothelin promoter variants are associated with increased soluble mesothelin-related peptide levels in asbestos-exposed individuals

Conclusions
These data support the suggestion that SMRP performance is affected by individual (ie, genetic) variables and that MSLN expression is influenced by SNPs located within the promoter regulatory region.

Source: Occupational and Environmental Medicine - May 24, 2017 Category: Occupational Health Authors: De Santi, C., Pucci, P., Bonotti, A., Melaiu, O., Cipollini, M., Silvestri, R., Vymetalkova, V., Barone, E., Paolicchi, E., Corrado, A., Lepori, I., DellAnno, I., Pelle, L., Vodicka, P., Mutti, L., Foddis, R., Cristaudo, A., Gemignani, F., Landi, S. Tags: Methodology Source Type: research