Blood biomarkers of carbohydrate, lipid, and apolipoprotein metabolisms and risk of amyotrophic lateral sclerosis: A more than 20 ‐year follow‐up of the Swedish AMORIS cohort

ObjectiveTo assess the associations of blood biomarkers of carbohydrate, lipid, and apolipoprotein metabolisms with the future risk of amyotrophic lateral sclerosis (ALS).
MethodsIn the Apolipoprotein‐related MOrtality RISk study, we enrolled 636,132 men and women during 1985–1996 in Stockholm, Sweden, with measurements of serum glucose, total cholesterol, triglycerides, apolipoprotein B (apoB), and apolipoprotein A‐I (apoA‐I). Serum low‐density lipoprotein cholesterol (LDL‐C) and high‐density lipoprotein cholesterol (HDL‐C) were either directly measured or calculated from total cholesterol, triglycerides, and apoA‐I. The cohort was followed until the end of 2011. We used Cox models and mixed‐effects models to, first, estimate the associations between these biomarkers and ALS incidence and, second, to assess the changes of these biomarkers during the 20 years before ALS diagnosis.
ResultsOne‐unit increase of LDL‐C (hazard ratio [HR] = 1.14; 95% confidence interval [CI] = 1.02–1.27), apoB (HR = 1.68; 95% CI = 1.17–2.42), and apoB/apoA‐I ratio (HR = 1.90; 95% CI = 1.29–2.78) was associated with a higher incidence of ALS. High glucose level (≥6.11mmol/L) was associated with a lower incidence (HR = 0.62; 95% CI = 0.42–0.93), whereas high LDL‐C/HDL‐C (≥3.50; HR = 1.50; 95% CI = 1.15–1.96) and high apoB/apoA‐I (≥0.90 for men, ≥0.8 for women; HR = 1.41; 95% CI = 1.04–1.90) ratios were associated with a higher incidence. During the ...

Source: Annals of Neurology - May 23, 2017 Category: Neurology Authors: Daniela Mariosa, Niklas Hammar, H åkan Malmström, Caroline Ingre, Ingmar Jungner, Weimin Ye, Fang Fang, Göran Walldius Tags: Research Article Source Type: research