GI highlights from the literature

Basic scienceThe complexities of host–microbiota interaction Gevers D, Kugathasan S, Denson LA, et al. The treatment-naïve microbiome in new-onset Crohn's Disease. Cell Host Microbe 2014;15:382–92. Crohn's disease is a complex disorder in which genetics and environmental factors establish and contribute to disease pathogenesis. Genetic studies implicate an underlying role for aberrant immune responses central to microbial sensing/signalling and mucosa-initiated effector responses. It is now well recognised that the gut microbiome plays an important role in disease pathogenesis but many current studies are confounded by size/power and treatment effects. To improve the understanding of the microbiota contribution to Crohn's disease pathogenesis, this study applied a standardised analysis approach to a large multi-centre cohort of new-onset Crohn's disease patient samples, collected prior to therapy. The study characterised mucosal-associated and faecal microbiota communities in Crohn's disease patients and a cohort of non-IBD patients. A total of 1321 samples including...
Source: Gut - Category: Gastroenterology Authors: Tags: JournalScan Source Type: research