Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome
Conclusions
Rs2349775 (NXPH1) and rs17837965 (CDC42) were associated with IBS-D and IBS-C, respectively, in two independent cohorts. Further studies are warranted to validate our findings and to determine the mechanisms underlying IBS pathophysiology.
Source: Gut - Category: Gastroenterology Authors: Wouters, M. M., Lambrechts, D., Knapp, M., Cleynen, I., Whorwell, P., Agreus, L., Dlugosz, A., Schmidt, P. T., Halfvarson, J., Simren, M., Ohlsson, B., Karling, P., Van Wanrooy, S., Mondelaers, S., Vermeire, S., Lindberg, G., Spiller, R., Dukes, G., D'Ama Tags: Constipation, Diarrhoea, Irritable bowel syndrome Neurogastroenterology Source Type: research
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