Can omega-3 help prevent Alzheimer's disease? Brain SPECT imaging shows possible link

(IOS Press) The incidence of Alzheimer's disease (AD) is expected to triple in the coming decades and no cure has been found. Recently, interest in dietary approaches for prevention of cognitive decline has increased. In particular, the omega-3 fatty acids have shown anti-amyloid, anti-tau and anti-inflammatory actions in the brains of animals.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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The objective of this study was to examine the prevalence of the coexistence of parkinsonism in patients with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD). METHODS: Outpatients were evaluated with Mini-Mental State Examination, Clinical Dementia Rating Scale, NIA-AA criteria, MRI, and 123I-IMP SPECT (3D-SSP). Parkinsonism in patients diagnosed with MCI (Mini-Mental State Examination ≥24, n = 63) or mild AD (Mini-Mental State Examination 20-23, n = 43) was examined using the Unified Parkinson's Disease Rating Scale-III and 123I-FP-CIT dopamine transporter SPECT. RESULTS: On...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
The objective of this study was to examine the prevalence of the coexistence of parkinsonism in patients with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD).MethodsOutpatients were evaluated with Mini–Mental State Examination, Clinical Dementia Rating Scale, NIA-AA criteria, MRI, and 123I-IMP SPECT (3D-SSP). Parkinsonism in patients diagnosed with MCI (Mini–Mental State Examination ≥24, n = 63) or mild AD (Mini–Mental State Examination 20–23, n = 43) was examined using the Unified Parkinson's Disease Rating Scale–III and 123I-FP-CIT dopamine transporter...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
CONCLUSION: Factors other than hypoperfusion, such as hypertension and diabetes mellitus, could be involved in the cognitive dysfunction of late-onset AD patients with high vascular risk. PMID: 30132427 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Abusing marijuana can add years to your brain's age. And so can bipolar disorder,...Read more on AuntMinnie.comRelated Reading: SNMMI: SPECT shows brain changes in football players SPECT links omega-3 with Alzheimer's prevention SPECT finds low cerebral blood flow in NFL players SPECT advocate Amen calls for modality's use in psychiatry SPECT may detect addictive behavior
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractAlzheimer ’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) of abnormal hyperphosphorylated tau protein are the pathological hallmarks of the disease, accompanied by other pathological processes such as microglia activation. Functional and molecular nuclear medicine imaging with single-photon emission computed tomography (SPECT) and positron emission tomography (PET) techniques provides valuable information about the underlying pathological processes, many years before the appearance of cl ini...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
A novel PET imaging technique could advance the ability to monitor and guide...Read more on AuntMinnie.comRelated Reading: Drug shortage puts PET, SPECT stress to the test PET could make synaptic density an Alzheimer's biomarker CT links brain calcifications to smoking, diabetes PET links amyloid, vascular factors to cognitive decline Diabetic patients should take heed of mild coronary artery disease
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ConclusionA decrease in cerebral α4β2 nAChR density could act as a biomarker reflecting cognitive impairments associated with AD pathology.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
This study investigated whether the clinical read of FPCIT SPECT predicts the patient’s survival. Patients from our clinical registry were included if they received an FPCIT SPECT between 10/2008 and 06/2016 and if their vital status (date of death, if applicable) could be determined in 07/2017. Cox proportional hazard models adjusted for age and sex were computed in order to test whether clinical reads of FPCIT scans (normal vs. pathological) predict survival. Analyses were stratified by indication for scanning (leading symptom: parkinsonism vs dementia). Vital status could be determined in 615/664 patients. 107 pat...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
Conclusion: The common CTAC-NDB with the spatial resolution compensation would be available in multicenter clinically, because the findings of the statistical images in patients with MCI and dementias showed similar tendency.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
1658Purpose: Although beneficial effects of acetyl-L-carnitine (ALC) in Alzheimer's disease (AD) have been reported, underlying neural correlates remain unclear. The current study aimed to investigate cerebral perfusion changes after ALC treatment in AD patients using technetium-99m hexamethylpropylene amine oxime single photon emission computed tomography (SPECT) METHOD AND MATERIALS: A total of 18 patients with early AD were recruited and assessed with brain SPECT, Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), and Neuropsychiatric Inventory (NPI). Changes in brain...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
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