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Can omega-3 help prevent Alzheimer's disease? Brain SPECT imaging shows possible link

(IOS Press) The incidence of Alzheimer's disease (AD) is expected to triple in the coming decades and no cure has been found. Recently, interest in dietary approaches for prevention of cognitive decline has increased. In particular, the omega-3 fatty acids have shown anti-amyloid, anti-tau and anti-inflammatory actions in the brains of animals.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Opinion statementProper diagnosis of dementia with Lewy bodies (DLB) in clinical practice remains suboptimal as many cases are misdiagnosed, usually as Alzheimer disease (AD) or Parkinson ’s disease (PD) and, in rare cases, psychosis. Therefore, it is important for patients with dementia to be thoroughly evaluated by a specialist who is familiar with current diagnostic tests and treatment options. New diagnostic criteria from the Dementia with Lewy Bodies Consortium have been devel oped to increase diagnostic sensitivity for DLB (Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DL...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
Abstract As lifespan tendency is increasing, age-related diseases are becoming a burden to the society and health care system. Mostly incurable, constitute a subject of researchers' work. In this review the insight into the problem of Alzheimer Disease (AD) diagnostics will be given. The unquestionable diagnosis is possible only during a post-mortem examination. AD is known as one of the forms of dementia and its differentiation from mild cognitive impairments has to be improved. Despite a great diagnostic progress during last decades, medicine still needs more accurate tools for an early detection of this incurab...
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research
CONCLUSION: In line with previous evidence, FDG-PET and rCBF-SPECT more accurately identified patients with AD than T1-MRI, and the addition of either PET or SPECT to T1-MRI data yielded increased accuracy. The comparable SPECT and PET performances, directly demonstrated for the first time in the present study, support the view that rCBF-SPECT still has a role to play in AD diagnosis. PMID: 28977066 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Psiquiatria - Category: Psychiatry Authors: Tags: Rev Bras Psiquiatr Source Type: research
The neural substrate of memory-deficit awareness has been studied in mild cognitive impairment and Alzheimer's disease (AD). However, little is known about that in dementia with Lewy bodies (DLB). To determine the neural substrates of memory-deficit awareness in DLB, we investigated the relationship between awareness of memory-deficit and glucose metabolism in DLB. Thirty-four patients with DLB were assessed by 18F-FDG-PET and dopamine transporter (DAT)-SPECT. The awareness was evaluated using an awareness index that represents the discrepancy between objective and subjective memory scores.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research
Ken-ichi Tabei, Hirotaka Kida, Tetsuo Hosoya, Masayuki Satoh, Hidekazu Tomimoto
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSIONS: The distinctions observed by us should be carefully considered in the visual assessments of Alzheimer disease. Further studies are required to define the patterns of change in arterial spin-labeling–MR imaging associated with Alzheimer disease.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
(IOS Press) In the largest functional brain imaging study to date, the Amen Clinics (Newport Beach, CA) compared 46,034 brain SPECT (single photon emission computed tomography) imaging studies provided by nine clinics, quantifying differences between the brains of men and women. The study is published in the Journal of Alzheimer's Disease.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
ConclusionThe two collimator designs provide superior image quality as compared to the conventional LEHR, and shows potential to improve current brain SPECT imaging based on a conventional SPECT scanner.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
AbstractEstablishing the in vivo diagnosis of Alzheimer ’s disease (AD) or other dementias relies on clinical criteria; however, the accuracy of these criteria can be limited. The diagnostic accuracy is 77% for a clinical diagnosis of AD, even among experts. We performed a review through PubMed of articles related to specific diagnostic modalities, inc ludingAPOE genotyping, cerebrospinal fluid (CSF) testing, fludeoxyglucose F 18 positron emission tomography (PET), amyloid PET, tau PET, computed tomography (CT), single-photon emission CT, magnetic resonance imaging (MRI), and B12 and thyroid-stimulating hormone scree...
Source: Neurology and Therapy - Category: Neurology Source Type: research
ConclusionResolution recovery caused variations in normal rCBF because counts increased in cerebral regions.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
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