Facial botryomycosis-like pyoderma in an HIV-infected patient: remission after initiation of darunavir and raltegravir

We report a 28-year-old woman who presented with a chronic, ulcerated lesion with draining sinuses in the right malar region. Predisposing factors were HIV infection with poor immunological control, alcoholism, and a previous trauma to the right cheek. Several courses of antimicrobial therapy provided only partial and temporary remission. Complete clinical remission was only achieved 5 years later when a novel antiretroviral regimen composed of darunavir and raltegravir was initiated.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

Related Links:

Publication date: Available online 24 December 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Mohammad Sabzi, Mohammad Javad Afshari, Masoud Babaahmadi, Nima ShafaghAbstractIn this work, a pH-sensitive and antibacterial drug delivery system based on poly(vinyl alcohol) (PVA)/citric acid (CA)/Ag nanoparticles (NPs) was designed using a completely green, facile and one-step route. Interestingly, the crosslinking of PVA with CA, and in-situ formation of Ag NPs within the polymeric matrix were simultaneously and simply carried out using an annealing process without need for any toxic chemicals. The developed hydr...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Abstract In this work, a pH-sensitive and antibacterial drug delivery system based on poly(vinyl alcohol) (PVA)/citric acid (CA)/Ag nanoparticles (NPs) was designed using a completely green, facile and one-step route. Interestingly, the crosslinking of PVA with CA, and in-situ formation of Ag NPs within the polymeric matrix were simultaneously and simply carried out using an annealing process without need for any toxic chemicals. The developed hydrogels were characterized by FTIR, UV-vis spectra, SEM and TEM techniques. It was found that CA not only acted as a crosslinker of PVA via esterification reaction, but al...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research
Authors: Tsujimoto Y, Kanzawa Y, Seto H, Nakajima T, Ishimaru N, Waki T, Kinami S Abstract Aeromonas hydrophila (A. hydrophila) occasionally causes necrotizing fasciitis (NF) and sepsis in immunocompromised hosts. NF is associated with high mortality. In cases of septic shock due to A. hydrophila, mortality is nearly 100%. Our 47-year-old male patient was diagnosed with NF and septic shock due to A. hydrophila. He had not been exposed to fresh or slightly salty water, which is where the bacterium is typically found, so its origin in this case is unclear. This is the first known case in which the patient was able to...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Semin Respir Crit Care Med 2019; 40: 508-523 DOI: 10.1055/s-0039-1693705Central venous catheter-related bloodstream infections (CR-BSI) are a frequent event in the intensive care unit (ICU) setting. In contrast to other nosocomial infections, most risk factors for CR-BSI are linked to the device and can be prevented efficiently. Rates of CR-BSI higher than 1 per 1,000 catheter days are no longer acceptable. A continuous quality improvement program is effective to reduce them. Key elements of prevention of CR-BSI are hand hygiene, avoidance of insertion of unnecessary catheters, full sterile barrier precautions at insertion...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
Aashish Gangrade, Swapnil M Parchand, Samrat Chatterjee, Anil Gangwe, Deepshika AgrawalIndian Journal of Ophthalmology 2019 67(7):1214-1216 We here report a case of scleral buckle infection with fulminant scleral abscess secondary to Moraxella species. A 54-year-old chronic alcoholic male with a history of retinal detachment repair, with scleral buckle 8 years prior, presented with complaints of severe pain, redness, and swelling in the right eye since 2 weeks. The patient was diagnosed with scleral buckle infection, the buckle was removed, and cultures revealed Moraxella species. The postoperative course included fulmina...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
In this study, a modern alternative approach to antibiotic therapy using photosensitiser encapsulated polymeric nanoparticles is presented. Cationic nanoparticles were prepared using a biodegradable and biocompatible polymer poly (lactic-co-glycolic acid), a stabiliser poly (vinyl alcohol) and chitosan. Dynamic light scattering and laser Doppler anemometry were used to determine particle size distribution and ζ-potential respectively. To quantify the antibacterial photodynamic effect of the nanoparticles, in vitro studies were performed using Staphylococcus saprophyticus subsp. bovis and Escherichia coli DH5 alpha to ...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
ConclusionC. canimorsus meningitis is a rare but increasingly important clinical entity occurring in patients of all ages, typically after dog exposure. While classically considered an infection among immunocompromised patients, most cases have occurred in previously healthy, immunocompetent persons. Diagnosis may be rapidly established by PCR, and this test should be considered in culture-negative cases with associated exposures. Outcome was generally favorable after a median antibiotic duration of 15  days.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
GI Dynamics (ASX:GID) said today it won FDA investigational device exemption approval to launch a pivotal trial of its EndoBarrier device designed for treating patients with type 2 diabetes and obesity, pending Institutional Review Board approval. The EndoBarrier device is a plastic gut sleeve designed to prevent the absorption of nutrients from food as it exits the stomach and enters the intestinal tract to treat type 2 diabetes and obesity, the Lexington, Mass.-based company said. The approval is a boon for the company, which has faced a number of hurdles with its device over the past few years, inclu...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Diabetes Food & Drug Administration (FDA) Regulatory/Compliance Weight loss GI Dynamics Source Type: news
CONCLUSIONS: Neonatal and paediatric HAIs are common adverse events at district and regional hospitals. This at-risk population should be prioritised for HAI surveillance and prevention through improved infection prevention practices and HH compliance. PMID: 29843857 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
ro-Marí JM Abstract The clinical and microbiological characteristics of pleuro-pulmonary infection (PPI) caused by Streptococcus intermedius is described, including 6 cases in the literature and 9 cases handled at the present centre. Out of the 15 patients, 12 were male; mean age at diagnosis was 62.06 ± 15 years. Twelve had risk factors for S. intermedius infection such as alcoholism in 5 (35.7%) patients, periodontal disease in 3 (24.6%) cases, chronic obstructive pulmonary disease in 3 (24.6%), and diabetes mellitus in 2 (14.2%). Cough was present in 12 (80%) patients and chest pain and dyspnea in...
Source: Revista Espanola de Quimioterapia - Category: Drugs & Pharmacology Authors: Tags: Rev Esp Quimioter Source Type: research
More News: Alcoholism | Allergy & Immunology | Antibiotic Therapy | Isentress | Prezista | Skin | Tropical Medicine