Motor cortex stimulation does not lead to  functional recovery after experimental cortical injury in rats.

CONCLUSION: The use of MCS as a standalone treatment did not improve motor impairments in a rat model of severe cortical damage given our specific treatment modalities. PMID: 28506001 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

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In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 11 September 2019Source: Journal of PhysiotherapyAuthor(s): Peter William Stubbs, Jesper Mortensen
Source: Journal of Physiotherapy - Category: Physiotherapy Source Type: research
Conclusions Random forests can classify brain PET as positive or negative for amyloid deposition and suggest key clinically relevant, regional features for classification.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
The notion that stroke care could one day take to the skies seems more likely...Read more on AuntMinnie.comRelated Reading: Mobile CT unit boosts efficiency of stroke triage Perfusion imaging expands window for stroke treatment UCLA offers ambulatory stroke care with mobile CT Mobile stroke units, spectral CT take spots on ECRI watch list Mobile stroke unit with CT scanner speeds care in Cleveland
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we applied a data-driven approach to construct a stroke atlas of the brain using hierarchical density clustering in large number of infarct lesions, assuming that voxels/regions supplied by a common end-artery tend to infarct together.MethodsA total of 793 infarct lesions on MRI scans of 458 patients were segmented and coregistered to MNI-152 standard brain space. Applying a voxel-wise data-driven hierarchical density clustering algorithm, we identified those voxels that were most likely to be part of same infarct lesions in our dataset. A step-wise clustering scheme was applied, where the clustering thresho...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Mobile stroke ambulances equipped with a CT scanner and medical personnel can...Read more on AuntMinnie.comRelated Reading: 3 CTA signs show which stroke patients can skip surgery Perfusion imaging expands window for stroke treatment Head CT algorithm a step toward faster stroke care Mobile stroke unit with CT scanner speeds care in Cleveland Ambulance with mobile CT cuts stroke treatment times
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: This case report suggests that further randomized studies may evaluate whether repeated IVtPA may be safe and effective in ERS occurring shortly after a previous stroke when patients experience a period of complete neurological regression, minor disability, and a small infarct volume. Should the hypothesis be confirmed, small volume core and wide volume penumbra at perfusion CT may support the decision of adopting IVtPA repetition.
Source: The Neurologist - Category: Neurology Tags: Case Report/Case Series Source Type: research
Inflow malposition during surgery, postoperative pump migration, inflow obstruction, and right ventricular compression are major contributors to low flow and adverse events in patients with ventricular assist devices (VADs). These position abnormalities can lead to adverse events including ischemic stroke. To address these problems, we conducted a virtual anatomical fitting study and hemodynamic simulation on iterative cannula designs, resulting in the EVAHEART 2 with the novel double-cuff tipless (DCT) inflow cannula and smaller pump design. Anatomical fitting was based on computed tomography scans of six patients with he...
Source: ASAIO Journal - Category: Medical Devices Tags: Biomedical Engineering Source Type: research
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