Kidney cancer: Targeting metabolism in RCC

Nature Reviews Nephrology 13, 320 (2017). doi:10.1038/nrneph.2017.57 Author: Susan. J. Allison Loss of VHL and elevated expression of HIF transcription factors leads to reprogramming of tumour cell metabolism, enabling renal cell carcinoma (RCC) cells to use carbons from glutamine-derived aspartate to drive pyrimidine biosynthesis. Now, researchers show that inhibition of glutamine availability decreases aspartate availability,
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research