Kidney cancer: Targeting metabolism in RCC
Nature Reviews Nephrology 13, 320 (2017).
doi:10.1038/nrneph.2017.57
Author: Susan. J. Allison
Loss of VHL and elevated expression of HIF transcription factors leads to reprogramming of tumour cell metabolism, enabling renal cell carcinoma (RCC) cells to use carbons from glutamine-derived aspartate to drive pyrimidine biosynthesis. Now, researchers show that inhibition of glutamine availability decreases aspartate availability,
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Susan. J. Allison Tags: Research Highlight Source Type: research
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