Tonic regulation of stationary asynchronous firing of a neural network

AbstractThe impact of tonic conductance upon population activity was investigated. An extra tonic transmembrane current through GABA-activated extrasynaptic GABAA-receptors was found to control stationary asynchronous firing both quantitatively and qualitatively. Quantitative regulation consisted in alterating a current level of stationary population activity while qualitative regulation manifested itself in appearance of resilient asynchronous spiking in case GABA reversal potential exceeded a certain threshold. The study was based on a modified rate model after Wilson and Cowan and backed up with a computer simulation of an explicit network model.
Source: Journal of Computational Neuroscience - Category: Neuroscience Source Type: research