Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation.

CONCLUSIONS: We have demonstrated that E2 can drive calcification in advanced atherosclerotic lesions by promoting the differentiation of VSMC to osteoblast-like cells, a process which is augmented by inhibition of estrogen receptor alpha or ERβ activity. PMID: 28473445 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28473445?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 4, 2017 Category: Cardiology Authors: McRobb LS, McGrath KCY, Tsatralis T, Liong EC, Tan JTM, Hughes G, Handelsman DJ, Heather AK Tags: Arterioscler Thromb Vasc Biol Source Type: research