Letter in response to remote ischaemic conditioning provides humoral cross-species cardioprotection through glycine receptor activation

We read with great interest the study by Alburquerque-B éjaret al.1 recently published inCardiovascular Research reporting that the cardioprotective effect of remote ischaemic conditioning (RIC) is related to remote glycine release in blood. Even if the protective mechanism of glycine remains unidentified, these results must be emphasized in the context of recent data reporting similar key involvement of glycine in human and rat with the use of different metabolomics techniques.2,3 Nevertheless, several other metabolites have been identified as potential effectors of RIC-induced protection such as kynurenine and kynurenine acid.2 –4 Hence glycine release may be part only of a more complex metabolic signalling mediated by RIC.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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