Analysis of the effects on the QT interval of a gatifloxacin-containing regimen versus standard treatment of pulmonary tuberculosis.

Conclusions: Neither a standard 6-month nor a 4-month gatifloxacin-based regimen appear to carry a sizeable risk of QT prolongation in patients with newly-diagnosed pulmonary tuberculosis. This is to-date the largest dataset studying the effects of anti-tuberculosis regimens on the QT, both for the standard regimen and for a fluoroquinolone-containing regimen.
PMID: 28438924 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - April 24, 2017 Category: Microbiology Authors: Olliaro PL, Merle C, Mthiyane T, Bah B, Kassa F, Amukoye E, N' Diaye A, Perronne C, Lienhardt C, Mcilleron H, Fielding K Tags: Antimicrob Agents Chemother Source Type: research