TTN Mutation May Not Rule Out Medical Therapy for Dilated Cardiomyopathy TTN Mutation May Not Rule Out Medical Therapy for Dilated Cardiomyopathy
In patients with dilated cardiomyopathy, loss-of-function mutations in the titin gene (TTN) do not preclude systolic function recovery following standard pharmacological therapy, according to Canadian researchers.Reuters Health Information
AbstractBackground Left ventricular contraction dyssynchrony (LVCD) has been related to induced ischemia and transmural scar but the interplay of myocardial viability and dyssynchrony is unknown. The aim of the present study was to establish the role of dyssynchrony in the context of a viability study performed with nitrate augmentation gated single photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI).Methods Fifty-four consecutive patients with ischemic dilated cardiomyopathy (IDC) and depressed left ventricular ejection fraction (LVEF) were included. They underwent a two-day rest/nitroglyce...
Publication date: Available online 30 March 2020Source: Redox BiologyAuthor(s): Cheng Zeng, Fengqi Duan, Jia Hu, Bin Luo, Binlong Huang, Xiaoying Lou, Xiuting Sun, Hongyu Li, Xuanhong Zhang, Shengli Yin, Hongmei Tan
Functional mitral regurgitation (FMR) in non-ischemic cardiomyopathy (NICM) may be partly related to the dysfunction of subvalvular apparatus. Thus, we sought to investigate the correlation between papillary muscle viability and FMR changes in NICM.
Patients with dilated cardiomyopathy (DCM) who achieved left ventricular reverse remodeling (LVRR) have a favorable prognosis, but it is still difficult to precisely predict LVRR in the clinical setting.
The underlying mechanisms of right ventricular (RV) dysfunction in patients with non-ischemic dilated cardiomyopathy (NICM) remain poorly defined. We evaluated a potential correlation between local mechanical dyssynhcrony of interventricular septum (IVS) and RV function in these patients.
Abstract The management of dilated cardiomyopathy (DCM) is well established. However, a subset of patients does not have recovery from or have recurrences of left ventricular (LV) dysfunction despite receiving optimal medical therapy. Coronary microvascular dysfunction (CMD) can result from structural and functional abnormalities at the intramural and small coronary vessel level affecting coronary blood flow autoregulation and consequently leading to impaired coronary flow reserve. Dilated myocardial phenotype may be responsible for CMD in DCM. Anisodamine can exert a significant effect on relieving microvascular ...
We reported the effect of CF VAD in small children with dilated cardiomyopathy refractory to conventional pharmacological treatment.
Danon Disease (DD) is a rare X-linked disorder due to mutations in the Lysosomal Associated Membrane Protein 2 (LAMP-2) gene. Patients present with cardiac manifestations of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). The goal of this study is to characterize the longitudinal progression of hypertrophic phenotypes and descriptions of left ventricular strain in DD.
Heart failure (HF) affects more than 6 million adults in the U.S and is associated with significant morbidity and mortality. The majority of HF patients suffer from either ischemic (ICM) or dilated (DCM) cardiomyopathy. Little is known about the genetic alterations in DCM or ICM patients. Therefore, our aim was to characterize differentially expressed genes in left ventricular tissue from DCM and ICM patients.
Myocarditis is a known etiology of both acute fulminant heart failure and chronic dilated cardiomyopathy requiring heart transplantation. We sought to evaluate the long-term post-transplant outcomes of pts with myocarditis.