A proposed mechanism of neuronal injury in pilots and aircrew personnel with hypobaric exposure (s53.005)

Conclusions:Significant declines in markers of neuronal integrity suggest that oxidative stress is evident within 24 hours of hypobaric exposure. The increase in CBF measured by ASL in subjects exposed to hypobaric conditions is a response to oxidative damage and is evidence of increased metabolic demand. This study provides evidence that white matter hyperintensity formation may occur because of repeated oxidative stress without adequate time for healing. Cerebral white matter hyperintensities in this population are likely a function of both cumulative effects as well as frequency of hypobaric exposure.Disclosure: Dr. Hossack has nothing to disclose. Dr. Sladky has nothing to disclose. Dr. McGuire has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: General Neurology: Mechanisms and Diagnosis in Overlapping Medical and Neurological Diseases Source Type: research