Approach towards an ALS-specific structural marker of motor tract integrity for the description of different ALS progression types using diffusion-weighted imaging (S53.003)

Conclusions:Diffusion-weighted FA may be considered as a MRI marker for the description of ALS-specific white matter pathology. The approach towards an ALS-specific structural marker for white matter degeneration linked to ALS-FRS-R decline may add in predicting disease progression.Study Supported by:The current study is funded by the German Federal Ministry of Education and Research (BMBF, Project GO-Bio).Disclosure: Dr. Wirth has nothing to disclose. Dr. Khomenko has nothing to disclose. Dr. Baldaranov has nothing to disclose. Dr. Johannesen has nothing to disclose. Dr. Kobor has nothing to disclose. Dr. Brunn has received personal compensation for activities with NeuroVision Pharma GmbH, Germany. Dr. Greenlee has nothing to disclose. Dr. Deppe has nothing to disclose. Dr. Bogdahn has nothing to disclose.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Wirth, A. M., Khomenko, A., Baldaranov, D., Johannesen, S., Kobor, I., Bruun, T.-H., Greenlee, M. W., Deppe, M., Bogdahn, U. Tags: General Neurology: Mechanisms and Diagnosis in Overlapping Medical and Neurological Diseases Source Type: research