Vitamin K Antagonists and Risk of Subdural Hematoma: Meta-Analysis of Randomized Clinical Trials [Clinical Sciences]

Conclusions— VKA use significantly increases the risk of subdural hematoma by 3-fold relative to antiplatelet therapy. Direct-acting oral anticoagulants are associated with a significantly reduced risk of subdural hematomas versus VKAs. Based on indirect comparisons to VKAs, the risks of subdural hematoma are similar with antiplatelet monotherapies and factor Xa inhibitors.
Source: Stroke - Category: Neurology Authors: Tags: Coumarins Clinical Sciences Source Type: research