CD4-Negative Variant of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm With a Novel PBRM1 Mutation in an 11-Year-Old Girl.

Conclusions: CD4- variant of BPDCN may be mistaken for myeloid sarcoma or extramedullary lymphoblastic leukemia/lymphoma because of their overlapping morphologic and immunophenotypic features; thus, a careful clinicopathologic evaluation is essential to reach the correct diagnosis. PBRM1 mutation seems to be a driver event in this case. Our study underscores the importance of alterations in chromatin remodeling in the pathogenesis of BPDCN. PMID: 28419186 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28419186?dopt=Abstract

Source: American Journal of Clinical Pathology - April 15, 2017 Category: Pathology Authors: Yigit N, Suarez LF, Roth LG, Orazi A, Tam W Tags: Am J Clin Pathol Source Type: research