Lupus nephritis: CD11b suppresses inflammation in SLE

Nature Reviews Nephrology 13, 262 (2017). doi:10.1038/nrneph.2017.50 Author: Shimona Starling Single-nucleotide polymorphisms (SNPs) in the ITGAM gene (which encodes the adhesion molecule CD11b) are associated with an increased risk of systemic lupus erythematosus (SLE). Faridi et al. show that ITGAM SNPs that reduce CD11b function correlate with elevated activity of pro-inflammatory
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research

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Roche has won the U.S. Food and Drug Administration's breakthrough therapy tag for its drug Gazyva in lupus nephritis, the Swiss drugmaker said on Wednesday, boosting its efforts to recycle the 2013-approved lymphoma medicine for new indications.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Roche today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) to Gazyva ® (obinutuzumab) for adults with lupus nephritis.
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Sjögren's syndrome in Systemic Lupus Erythematosus - a subset characterized by a systemic inflammatory state. J Rheumatol. 2019 Sep 15;: Authors: Ruacho G, Kvarnström M, Zickert A, Oke V, Rönnelid J, Eketjäll S, Elvin K, Gunnarsson I, Svenungsson E Abstract OBJECTIVE: Secondary Sjögren's syndrome (SLE-sSS) is an often-neglected subset of patients with Systemic lupus erythematosus (SLE). Furthermore, primary Sjögren's syndrome overlaps and can be difficult to delineate from SLE. To shed light on the SLE-sSS subset, we investigated a large and well-characterized SLE cohort c...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES. Trans Am Clin Climatol Assoc. 2019;130:88-99 Authors: Tsokos GC, Tsokos MG Abstract We have found that calcium calmodulin kinase IV is increased in T cells, podocytes, and mesangial cells from patients with systemic lupus erythematosus, as well as in lupus-prone mice, podocytes of patients with focal segmental glomerulosclerosis, and in mice injected with doxorubicin. We showed that this accounts for aberrant T cell function and glomerular damage. Using nanoparticles (nlg) loaded with a small drug inhibitor of calcium calmodulin ki...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
ConclusionNLR and PLR appear to be potentially useful cheap parameters of activity, relapse and severity in SLE patients with nephritis.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Joyita Bharati, Manish Rathi, Raja Ramachandran, Aman Sharma, Vivek Kumar, Harbir Singh Kohli, Krishan Lal GuptaIndian Journal of Nephrology 2019 29(5):373-375
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
In this study we analyzed sera from 191 patients with SLE, 119 patients with primary Sjögren's syndrome (pSS), 48 patients with systemic sclerosis (SSc), and 100 healthy donors (HD) for autoantibodies to eight different KIRs. Anti-KIR autoantibodies were identified in sera from 23.0% of patients with SLE, 10.9% of patients with pSS, 12.5% of patients with SSc, and 3.0% of HD. IgG from anti-KIR-positive SLE patients reduced the degranulation and cytotoxicity of NK cells toward K562 tumor cells. The presence of anti-KIR-autoantibodies reacting with>3 KIRs was associated with an increased disease activity (p
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Fetal complications were frequent in patients with LN. Umbilical arterial Doppler ultrasonography was a useful measure to predict late IUGR, fetal distress, and the composite APOs. PMID: 31495267 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
Lupus nephritis (LN) is an inflammation of the kidneys and is a major cause of mortality in systemic lupus erythaematosus (SLE) patients. In addition, Th17/Treg balance is one of the most important factors tha...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Abstract Inflammation plays a key role in the pathogenesis of lupus nephritis (LN) and inflammatory cytokines within the glomeruli are critical in this process. However, little information is available for the identities of the cell types that are primarily responsible for the production and function of the various cytokines. We have devised a novel method to visualize cytokine signals in the kidney by confocal microscopy and found that cytokine production within the glomerulus is cell type-specific and under translational control. In the lupus-prone NZM2328 mice with chronic glomerulonephritis, IL-6, IL-1β, ...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
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