Lupus nephritis: CD11b suppresses inflammation in SLE

Nature Reviews Nephrology 13, 262 (2017). doi:10.1038/nrneph.2017.50 Author: Shimona Starling Single-nucleotide polymorphisms (SNPs) in the ITGAM gene (which encodes the adhesion molecule CD11b) are associated with an increased risk of systemic lupus erythematosus (SLE). Faridi et al. show that ITGAM SNPs that reduce CD11b function correlate with elevated activity of pro-inflammatory
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research