The role of the TOR pathway in mediating the link between nutrition and longevity

Publication date: Available online 16 March 2017 Source:Mechanisms of Ageing and Development Author(s): Oleh Lushchak, Olha Strilbytska, Veronika Piskovatska, Kenneth B. Storey, Alexander Koliada, Alexander Vaiserman The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR regulates longevity of various organisms in response to dietary conditions. In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging. The potential contribution of the TOR pathway in lifespan-extending effects of varied dietary interventions, and the anti-aging drugs rapamycin and metformin direct or indirect regulation of TOR activity in yeasts, worms, flies and mammals are also discussed.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research