PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury

Conclusions Our data demonstrate for the first time that PGAM5 plays an indispensable role in the pathogenesis of ConA-induced liver injury. Downstream of PGAM5, Drp1-mediated mitochondrial fission is an obligatory step that drives the execution of hepatic necrosis and tissue damage. Our data highlight the PGAM5-Drp1 axis as a potential therapeutic target for acute immune-mediated liver injury.

http://gut.bmj.com/cgi/content/short/66/4/716?rss=1

Source: Gut - March 10, 2017 Category: Gastroenterology Authors: He, G.-W., Günther, C., Kremer, A. E., Thonn, V., Amann, K., Poremba, C., Neurath, M. F., Wirtz, S., Becker, C. Tags: Hepatitis other Hepatology Source Type: research