Ten million lives saved by 1962 breakthrough, study says

Nearly 200 million cases of polio, measles, mumps, rubella, varicella, adenovirus, rabies and hepatitis A -- and approximately 450,000 deaths from these diseases -- were prevented in the US alone between 1963 and 2015 by vaccination, researchers estimate.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 21 July 2018Source: Social Science &MedicineAuthor(s): Rebekah Burroway, Andrew HargroveAbstractNigeria is an interesting case study because it outperforms other lower middle-income countries in economic development, yet ranks among the lowest in the world in immunization coverage rates. Combining multi-level modeling with spatial data techniques, this study investigates the individual- and community-level factors that influence the likelihood that a child is fully immunized, underscoring the importance of maternal education for improving child health. Drawing on data from the Demogra...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 21 July 2018Source: Veterinary MicrobiologyAuthor(s): Gerald L. Murray, Theeraya Simawaranon, Chamraj Kaewraemruaen, Ben Adler, Rasana W. SermswanAbstractA previously-described live, attenuated vaccine (M1352, serovar Manilae, serogroup Pyrogenes) was tested in the hamster model of infection for cross-protective immunity. The vaccine elicited strong, significant cross-protection against lethal infection by strains representing four serologically distinct leptospiral serovars (Grippotyphosa, Australis, Canicola, and Autumnalis). Combined with our previously reported protection against sero...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: October 2018Source: Fish &Shellfish Immunology, Volume 81Author(s): Pengfei Mu, Yuhua Wang, Jingqun Ao, Chunxiang Ai, Xinhua ChenAbstractInterleukin-2 (IL-2), an important immunomodulatory cytokine, plays a crucial role in promoting the proliferation, activation and differentiation of T cells. Here, the cDNA of an IL-2 homologue (LcIL-2) in large yellow croaker (Larimichthys crocea) was cloned by RACE-PCR techniques. The open reading frame (ORF) of LcIL-2 gene is 426 bp long and encoded a precursor protein of 141 amino acids (aa), with a 20-aa signal peptide and a 121-aa mature peptide containing two ...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
ConclusionThe treatment of chronic HCV infection for genotypes 1, 2 or 3 with the therapeutic regimens established by the Brazilian guidelines showed high rates of SVR, even in cirrhotic patients.
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
The objective was to evaluate the effects of injectable trace minerals (ITM) concurrent with modified-live virus (MLV) vaccination on protection from bovine viral diarrhea virus (BVDV) infection in dairy calves. In a previous study (Palomares et al., 2016), thirty dairy calves received two doses of a MLV vaccine subcutaneously (SC), concurrently with ITM (n = 15) or saline (n = 15), SC. Five months later, 20 of these calves received ITM (G1, n = 10) or saline (G2, n = 10) according to their previous groups and were challenged intranasally with BVDV2. Five unvaccinated calves were also challenged with BVDV2 ...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
CONCLUSION: This study reported high rates of HBV markers of infection among SCD patients. It is therefore advocated that donated blood must pass through rigorous screening processes before it is transfused. PMID: 30024816 [PubMed - as supplied by publisher]
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
Publication date: September 2018Source: Molecular Immunology, Volume 101Author(s): Hyun Young Kim, Sun Kyung Kim, Ho Seong Seo, Soyoung Jeong, Ki Bum Ahn, Cheol-Heui Yun, Seung Hyun HanAbstractDendritic cells (DCs) play an important role in antigen presentation, which is an essential step for the induction of antigen-specific adaptive immunity. Inactivated bacterial whole cell vaccines have been widely used to prevent many bacterial infections because they elicit good immunogenicity due to the presence of various antigens and are relatively inexpensive and easy to manufacture. Recently, gamma-irradiated whole cells of none...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
In conclusion, silvestrol could be identified as pangenotypic HEV replication inhibitor in vitro with additive effect to RBV and further demonstrated high potency in vivo. The compound therefore may be considered in future treatment strategies of chronic hepatitis E in immunocompromised patients.
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 20 July 2018Source: Veterinary MicrobiologyAuthor(s): Yujuan Niu, Qinqin Sun, Guihua Zhang, Xingpo Liu, Yiling Shang, Yihong Xiao, Sidang LiuAbstractFowl adenovirus serotype 4 (FAdV-4) is a hepatotrophic virus that causes severe liver diseases. Upon histological examination, the most remarkable findings in the liver are small multifocal areas of necrosis and mononuclear cell infiltration, including basophilic intranuclear inclusion bodies in hepatocytes surrounded by a clear halo or which fill the entire nucleus. Here, we examined the mechanism responsible for FAdV-4-mediated hepatocyte d...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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