25: association of serum gamma- interferon and il-10 concentrations with insulin resistance in major thalassemia patients

Conclusion: In this study, interferon-gamma as an inflammatory cytokine and interlukin-10 as an anti-inflammatory cytokines was studied. Overall these results suggest that interleukin-10 is associated with insulin resistance in non-splenectomized major thalassemia patients and as an anti-inflammatory cytokine may play an important role in sustaining insulin resistance in non-splenectomized major thalassemia patients. With increase in serum IL-10 levels there is a decline in insulin resistance. This data provide new insights into the mechanisms of insulin resistance and support the use of other cytokines with insuln resistance in major thalassemia patients.
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access Poster Source Type: research