Popular heartburn drugs linked to gradual yet'silent' kidney damage

The sudden onset of kidney problems often serves as a warning for doctors to discontinue patients'use of proton pump inhibitors (PPIs), sold under brand names Prevacid, Prilosec, Nexium and Protonix, among others. But a new study indicates that more than half of patients who develop chronic kidney damage while taking the drugs don't experience acute kidney problems beforehand, according to researchers.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Goal: The goal of this study was to determine the relationship of reflux with gastroparesis (Gp), looking both at symptoms and objective testing. Background: Gp patients often experience gastroesophageal reflux symptoms. How the severity of reflux correlates with the severity of Gp is not known. Study: Patients referred to our academic center with symptoms of Gp completed the Patient Assessment of Upper Gastrointestinal Symptoms, Hospital Anxiety and Depression Scale, and Patient Health Questionnaire (PHQ)-15. They underwent 4-hour gastric emptying scintigraphy; and, if indicated, high-resolution esophageal manomet...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Monday, April 6, 2020 (American Heart Association News) -- Doug Cobb popped a couple antacid pills to calm the heartburn he'd been experiencing on and off for weeks. The 60-year-old considered he might have a stomach problem, but waved it off,...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Authors: Hoshikawa Y, Sawada A, Sonmez S, Nikaki K, Woodland P, Yazaki E, Sifrim D Abstract Background/Aims: Mean nocturnal baseline impedance (MNBI) during multichannel intraluminal impedance pH-monitoring (MII-pH) reflects the status of esophageal mucosal integrity. MNBI is suggested as an adjunctive method to distinguish patients with true gastroesophageal reflux disease (GERD) from functional heartburn (FH) and might predict outcomes for anti-reflux treatment. However, current methodology for calculation of MNBI is time-consuming and subject to operator-dependent selection bias. We aim to simplify and provide a...
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
Update: On April 1, 2020, the FDA requested manufacturers to withdraw all prescription and over-the-counter (OTC) ranitidine drugs (Zantac, others) from the market immediately, due to the presence of a contaminant known as N-Nitrosodimethylamine (NDMA). Although the FDA did not observe unacceptable levels of NDMA in many of the samples they tested, they have determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures. As a result of this recall, ranitidine products will no longer be available for prescription or OTC use in the US. The FDA is also advising co...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Drugs and Supplements Source Type: blogs
Title: FDA Pulls Heartburn Drug Zantac From MarketCategory: Health NewsCreated: 4/1/2020 12:00:00 AMLast Editorial Review: 4/2/2020 12:00:00 AM
Source: MedicineNet Digestion General - Category: Nutrition Source Type: news
New findings about N-Nitrosodimethylamine (NDMA) contamination of this type of heartburn medication led to the U.S. Food and Drug Administration's (FDA's) more drastic action.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Six months after independent testing first raised the possibility that popular heartburn drug ranitidine (Zantac) might break down into the powerful carcinogen n-nitrosodimethylamine (NDMA), the FDA has asked for the removal of all ranitidine products from the market.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Heartburn medication made by Sanofi of France has been linked to cancer-causing impurity
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
FDA orders drugmakers to pull popular heartburn medications that contain trace amounts of a carcinogen.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
The US Food and Drug Administration is requesting that manufacturers pull all prescription and over-the-counter ranitidine drugs, known by the brand name Zantac, from the market immediately, the agency announced on Wednesday.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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