Vascular Cells in Blood Vessel Wall Development and Disease.
Vascular Cells in Blood Vessel Wall Development and Disease.
Adv Pharmacol. 2017;78:323-350
Authors: Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM
Abstract
The vessel wall is composed of distinct cellular layers, yet communication among individual cells within and between layers results in a dynamic and versatile structure. The morphogenesis of the normal vascular wall involves a highly regulated process of cell proliferation, migration, and differentiation. The use of modern developmental biological and genetic approaches has markedly enriched our understanding of the molecular and cellular mechanisms underlying these developmental events. Additionally, the application of similar approaches to study diverse vascular diseases has resulted in paradigm-shifting insights into pathogenesis. Further investigations into the biology of vascular cells in development and disease promise to have major ramifications on therapeutic strategies to combat pathologies of the vasculature.
PMID: 28212800 [PubMed - in process]
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM Tags: Adv Pharmacol Source Type: research