Emerging insights into the biology of typhoid toxin.

Emerging insights into the biology of typhoid toxin. Curr Opin Microbiol. 2017 Feb 14;35:70-77 Authors: Fowler CC, Chang SJ, Gao X, Geiger T, Stack G, Galán JE Abstract Typhoid toxin is a unique A2B5 exotoxin and an important virulence factor for Salmonella Typhi, the cause of typhoid fever. In the decade since its initial discovery, great strides have been made in deciphering the unusual biological program of this toxin, which is fundamentally different from related toxins in many ways. Purified typhoid toxin administered to laboratory animals causes many of the symptoms of typhoid fever, suggesting that typhoid toxin is a central factor in this disease. Further advances in understanding the biology of this toxin will help guide the development of badly needed diagnostics and therapeutic interventions that target this toxin to detect, prevent or treat typhoid fever. PMID: 28213043 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research

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Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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CONCLUSION: S-TREM-1 may be considered as a novel biomarker for such diagnosis of enteric fever with good sensitivity and specificity. PMID: 32026790 [PubMed - as supplied by publisher]
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
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