Microbiota-induced obesity requires farnesoid X receptor

Conclusions Our results indicate that the gut microbiota promotes diet-induced obesity and associated phenotypes through FXR, and that FXR may contribute to increased adiposity by altering the microbiota composition.
Source: Gut - Category: Gastroenterology Authors: Tags: Open access Gut microbiota Source Type: research

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Current data suggest that obesity does not impact survival, but may predispose patients to a higher rate of adverse events during left ventricular assist device (LVAD) support. We performed a systematic review and meta-analysis to assess the effects of obesity on clinical outcomes in LVAD recipients. We searched Medline, Scopus, Cochrane library, and clinicaltrials.gov from inception to February 2019 for studies comparing outcomes in obese (body mass index [BMI]> or ≥30 kg/m2) and nonobese (BMI1 year) all-cause mortalities. The estimates are presented as random-effects risk ratios (RR) with 95% confidence intervals. ...
Source: ASAIO Journal - Category: Medical Devices Tags: Adult Circulatory Support Source Type: research
Characteristics of non ‐obese Asians with elevated 1‐h plasma glucose are unknown. Individuals with elevated 1‐h plasma glucose have lower insulinogenic index and adiponectin. Insulin sensitivity was similar between the low and high 1‐h plasma glucose groups. AbstractElevated 1 ‐h plasma glucose (1h‐PG; ≥155 mg/dL) during an oral glucose tolerance test is a risk factor for type 2 diabetes. However, the metabolic characteristics of non‐obese Asians with elevated 1h‐PG are unknown. Thus, we studied 59 non‐obese Japanese men with normal glucose tolerance. We div ided study participants into the Low 1h‐PG group (
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Short Report Source Type: research
AbstractUrsodeoxycholic acid (UDCA) is a secondary bile acid that is used to treat primary biliary cholangitis. Although UDCA has a hepatoprotective effect in some diseases, its benefit in nonalcoholic fatty liver disease (NAFLD) remains controversial. We aimed to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of UDCA in overweight subjects with elevated liver enzymes after multiple administrations of UDCA and compare these changes with vitamin E treatment. Overweight subjects (body mass index, 25 ‐30 kg/m2) with elevated alanine aminotransferase (ALT) level (40 ‐200 IU/L) were enrolled. Subject...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
ConclusionsEnergy ‐rich meals induced hyperglycemia, hyperlipemia, an inflammatory response and a decrease in antioxidant markers. A meal typical for the Mediterranean diet resulted in favorable effects on glycemic, insulinemic and lipemic responses.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
AbstractPurpose of ReviewIndividuals with metabolically unhealthy normal weight (MUNW) have an adverse cardiometabolic risk factor profile in the absence of excess body weight, and increased risk for diabetes and heart disease. We critically review some physiological traits and lifestyle characteristics of the MUNW phenotype.Recent FindingsThe prevalence of MUNW varies considerably around the world and among ethnicities, partly because of different definitions; on average, this phenotype affects about ~  30% of normal weight persons globally. Most studies have recruited MUNW subjects who, although within the normal ...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Identification of genetic variants associated with specific conditions has been a going concern for some time, but the creation of large national databases of genetic and biometric data in a number of countries has greatly expanded this area of study. In today's research materials, scientists demonstrate one way in which this can be used, as a confirmation of the importance of hypertension and obesity in present variations in human life expectancy. People with genetic variants that increase the odds of suffering either of these conditions tend to live shorter lives, something that also shows up in standard epidemiological ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
(Natural News) Quercetin is a plant pigment or flavonoid that’s present in fruits, vegetables, seeds and grains. It is considered one of the most abundant antioxidants in the human diet. Apart from its antioxidant activities, quercetin is also known for having other beneficial properties, such as anti-inflammatory, anti-hypertensive, anti-obesity and even anti-cancer activities. In an recent study published in The...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Resumo Atualmente a obesidade é considerada um dos maiores desafios da saúde pública. Ela vem sendo enfrentada a partir do incentivo de mudanças comportamentais individuais, exaltando a perda de peso como forma inquestionável de garantir saúde. Tendo em vista este contexto e a importância das Diretrizes brasileiras de obe sidade sobre o campo da obesidade, sua influência sobre a prática profissional, o tipo de tratamento incentivado e o processo decisório em relação aos corpos gordos, foi realizada uma análise deste documento, associad...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
Publication date: March–April 2020Source: Heart &Lung, Volume 49, Issue 2Author(s): Zachary Cox, Pikki Lai, Connie Lewis, JoAnn Lindenfeld
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
AbstractThe family of AlkB homolog (ALKBH) proteins, the homologs ofEscherichia coli AlkB 2 ‐oxoglutarate (2OG), and Fe(II)‐dependent dioxygenase are involved in a number of important regulatory processes in eukaryotic cells including repair of alkylation lesions in DNA, RNA, and nucleoprotein complexes. There are nine human and thirteenArabidopsis thaliana ALKBH proteins described, which exhibit diversified functions. Among them, human ALKBH5 and FaT mass and Obesity ‐associated (FTO) protein and Arabidopsis ALKBH9B and ALKBH10B have been recognized as N6 methyladenine (N6meA) demethylases, the most abundant posttra...
Source: IUBMB Life - Category: Research Authors: Tags: SPECIAL ISSUE Source Type: research
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