Australian Aboriginal children with otitis media have reduced antibody titres to specific nontypeable Haemophilus influenzae vaccine antigens.

Australian Aboriginal children with otitis media have reduced antibody titres to specific nontypeable Haemophilus influenzae vaccine antigens. Clin Vaccine Immunol. 2017 Feb 01;: Authors: Thornton RB, Kirkham LS, Corscadden KJ, Wiertsema SP, Fuery A, Jones BJ, Coates HL, Vijayasekaran S, Zhang G, Keil A, Richmond PC Abstract Indigenous populations experience high rates of otitis media (OM), with increased chronicity and severity compared to that experienced by their non-Indigenous counterparts. Data are lacking on immune responses to otopathogenic bacteria in these high-risk populations. Non-typeable Haemophilus influenzae (NTHi) is the predominant otopathogen in Australia. Currently no vaccines are licensed to target NTHi, however Protein D (PD) from NTHi is included as a carrier protein in the 10-valent pneumococcal conjugate vaccine PHiD10-CV, and other promising protein vaccine candidates exist, including outer membrane proteins P4 and P6. We measured serum and salivary IgA and IgG to PD, P4 and P6 in Aboriginal and non-Aboriginal children with chronic OM undergoing surgery, and compared these to healthy non-Aboriginal children (controls). We found that Aboriginal cases had lower serum IgG titres to all NTHi proteins assessed, particularly PD. In contrast, serum IgA, and salivary IgA and IgG titres to each of these 3 proteins were equivalent or higher when compared to both non-Aboriginal cases and healthy controls. While serum an...
Source: Clinical and Vaccine Immunology - Category: Allergy & Immunology Authors: Tags: Clin Vaccine Immunol Source Type: research