Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells

Conclusions
We have discovered abnormal upregulation of a lncRNA, HNF1A-AS1, in human EAC. Our findings suggest that dysregulation of HNF1A-AS1 participates in oesophageal tumorigenesis, and that this participation may be mediated, at least in part, by modulation of chromatin and nucleosome assembly as well as by H19 induction.

Source: Gut - May 5, 2014 Category: Gastroenterology Authors: Yang, X., Song, J. H., Cheng, Y., Wu, W., Bhagat, T., Yu, Y., Abraham, J. M., Ibrahim, S., Ravich, W., Roland, B. C., Khashab, M., Singh, V. K., Shin, E. J., Yang, X., Verma, A. K., Meltzer, S. J., Mori, Y. Tags: Oesophageal cancer Oesophagus Source Type: research