First itraconazole resistant Aspergillus fumigatus clinical isolate harbouring a G54E substitution in Cyp51Ap in South America.

CONCLUSIONS: This is the first report in South America of a clinical A. fumigatus strain carrying the substitution G54E at Cyp51Ap associated with itraconazole resistance. Considering the patient was azole-naive, this resistant isolate may have been acquired from the environment. PMID: 28087293 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28087293?dopt=Abstract

Source: Revista Iberoamericana de Micologia - January 9, 2017 Category: Biology Authors: Leonardelli F, Theill L, Nardin ME, Macedo D, Dudiuk C, Mendez E, Gamarra S, Garcia-Effron G Tags: Rev Iberoam Micol Source Type: research