Acridone alkaloids from Vepris verdoorniana (Excell & amp; Mendon ça) Mziray (Rutaceae)

Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Albert Fouda Atangana, Flavien Aristide Alfred Toze, Moses K. Langat, Emmanuel Ngeufa Happi, Luc Leonard Meva’a Mbaze, Dulcie A. Mulholland, Alain François Kamdem Waffo, Norbert Sewald, Jean Duplex Wansi Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known compounds were isolated from methanol extracts of the roots and leaves of Vepris verdoorniana. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI- and ESI–MS). The 13C NMR values of 1,2,3,5-tetramethoxy-N-methylacridone (2) and 5-methoxyaborinine (3) are also reported. The crude extracts and compounds (1-6) were tested for their antimicrobial activity. The test delivered moderate activities for crude extracts and compounds 1, 5 and 6 against the bacterium Staphylococcus aureus and the fungi Mucor meihei and Candida albicans with MIC values between 115 and 180μg/mL for extracts and between 21.3 and 29.4μM for compounds, compared to gentamycin with 0.2μM and nystatin with 5.2μM against both fungi. The determination of the radical scanvenging activity using 1,1-dephenyl-2-picrylhydrazyl (DPPH) assay gave moderate antioxidant values for all tested compounds, with IC50 between 0.29 and 0.41μM, compared to the standard 3-t-butyl-4-hydroxyanisole (BHA) displaying 0.03μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research