Elevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation [MYOCARDIAL REVASCULARIZATION]

CONCLUSIONS This study provides the first description of atrial myocardial and circulating plasma microRNA in POAF patients. Our findings suggest POAF may be associated with pre-existing atrial substrate differences predisposing to arrhythmogenesis. Moreover, this study highlights the potential for miR-483-5p in biomarker development. Further work must now perform prospective, targeted validation of these results in a larger patient cohort.

http://ejcts.oxfordjournals.org/cgi/content/short/51/1/73?rss=1

Source: European Journal of Cardio-Thoracic Surgery - January 10, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Harling, L., Lambert, J., Ashrafian, H., Darzi, A., Gooderham, N. J., Athanasiou, T. Tags: History, Myocardial infarction MYOCARDIAL REVASCULARIZATION Source Type: research