Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS

Conclusions and implications In summary, this study shows that JAK inhibition ameliorates inhaled LPS-induced airway inflammation in rats, suggesting that at least JAK/STAT3 signalling is involved in the establishment of the pulmonary neutrophilia induced by LPS. JAKs inhibitors should be further investigated as a potential therapy for respiratory inflammatory diseases.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research