Two years, multiple doctors often needed to diagnose polycystic ovary syndrome, study shows
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder – and most common cause of infertility – affecting 9 to 18 percent of women around the world. Despite the prevalence of the complex and chronic condition, one-third of women diagnosed with PCOS saw at least three health professionals over the course of two years before receiving a diagnosis, acc ording to a new study.
Conditions: Infertility; Polycystic Ovary Syndrome Intervention: Behavioral: Fasting Sponsor: Cairo University Recruiting
AbstractPurposeTo evaluate the potential application of a nomogram based on woman ’s age and ovarian reserve markers as a tool to optimize the follicle-stimulating hormone (FSH) starting dose in intrauterine insemination (IUI) cycles.MethodsWe conducted a retrospective analysis enrolling 179 infertile women undergoing controlled ovarian stimulation (COS), followed by IUI. Each woman received an FSH starting dose according to clinical decision. After collecting data about COS and IUI procedures, we calculated the FSH starting dose according to the nomogram. The main outcomes measured were women ’s baseline chara...
Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It...
CONCLUSION: Overall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF. These benefits might not be evident upon having sufficient vitamin D levels. TRIAL REGISTRATION: This study was retrospectively registered in the Iranian website ( www.irct.ir ) for clinical trials registration ( http://www.irct.ir : IRCT20170513033941N27). PMID: 30286768 [PubMed - in process]
Polycystic ovary syndrome (PCOS) is a reproductive, endocrine, and metabolic disorder affecting millions of women worldwide. Women with PCOS are often identified in adolescence or early adulthood with symptoms of oligomenorrhea or hirsutism or when presenting for infertility care. The health risks associated out of PCOS, however, go far beyond management of these common presenting symptoms or fertility treatment and likely extend past the reproductive years through and beyond menopause. International surveys suggest that most patients are dissatisfied with long-term counseling related to medical and psychologic issues.
Abstract Telomeres are repeated DNA sequences whose main function is to preserve genome stability, protecting chromosomes ends from shortening caused by progressive loss during each cell replication or DNA damage. Telomere length regulation is normally achieved by telomerase enzyme, whose activity is progressively shut off during embryonic differentiation in somatic tissues, whereas it is maintained in germ cells, activated lymphocytes, and certain types of stem cell populations. The maintenance of telomerase activity for a longer time is necessary for germ cells to delay telomere erosion, avoiding thus chromosome...
CONCLUSION: In summary, Th1 and Th17 bias and reduction of Treg and Th2 cells as regulators of immune responses might be involved in the pathogenesis of PCOS. These results are suggestive of an altered immune response to inflammatory status in PCOS patients, likely causing some complications such as infertility in these patients. PMID: 30246693 [PubMed - in process]
ConclusionThis study showed that PRL, AMH, Age, SGPT, and history of abortion are affecting factors for distinguishing the phenotypes of PCOS.
Testosterone levels vary depending on a person ’s sex, age, and physical activity levels. Testosterone levels that are too high or too low may cause a range of potential complications including infertility and polycystic ovary syndrome (PCOS). Learn more about testosterone levels here.