Pancreatic Cancer: Targeted Co ‐delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer (Small 2/2017)

A new type of tumor‐targeted nanovehicle (PSPGP) is successfully synthesized for co‐delivery of PTX (paclitaxel) and TR3 siRNA, by G. Yu, G. Tang, and co‐workers in article number 1602697. In vitro and in vivo investigations demonstrate that the redox‐responsive PSPGP exhibited enhanced endosomal escape and intracellular degradation, which facilitates PTX and TR3 siRNA release, effectively improving the anti‐tumor efficacy.

Source: Small - January 5, 2017 Category: Nanotechnology Authors: Yang Li, Hebin Wang, Kai Wang, Qinglian Hu, Qi Yao, Youqing Shen, Guocan Yu, Guping Tang Tags: Frontispiece Source Type: research