Wilmot Discovery Improves Use of Umbilical Cord Blood as Cancer Therapy

A clinician/scientist, who studies ways to make cord-blood transplants for leukemia and lymphoma patients safer and more effective, recently reported a new finding in the journal, Blood. An accompanying editorial called the research “a breath of fresh air” for overcoming barriers to make this a viable option for many patients.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Source Type: news

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CONCLUSIONS: Caution is required when interpreting spatial distributions of patients, given inaccuracies in residential addresses and referral patterns to the hospital, and with HIV and other infections probable important confounders. Our study therefore shows that active case recruitment is required for accurate assessment of residential information. However, some findings on spatial distributions in the study warrant the continuation of efforts to develop a study protocol to investigate the possible link between uranium exposure in mining areas and haematological malignancies in residents. Disproportionately high inciden...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. It is characterized by the accumulation of CD19+/CD5+ lymphocytes and can have variable outcomes. Richter syndrome (RS) is a lethal complication in CLL patients that results in aggressive B-cell lymphomas, and there are no tests to predict its occurrence. Because alterations in microRNA expression can predict the development and progression of several cancers, we investigated whether dysregulation of specific microRNAs can predict RS in CLL patients. Thus, we compared microRNA expression levels in samples from 49 CLL patients who later developed RS with ...
Source: Blood - Category: Hematology Authors: Tags: Lymphoid Neoplasia, Brief Reports Source Type: research
Conditions:   Acute Biphenotypic Leukemia;   Acute Leukemia;   Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Hairy Cell Leukemia;   Interleukin-3 Receptor Subunit Alpha Positive;   Recurrent Acute Lymphoblastic Leukemia;   Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm;   R ecurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Recurrent Hematologic Malignancy;   Recurrent Hodgkin Lymphoma;   Refractory Acute Lymphoblastic Leukemia;  ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article summarizes the milestones in the development of duvelisib leading to these first approvals for CLL/SLL and FL.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionsMucormycosis involved mainly the sinu ‐orbital site and affected children>10  years. Despite aggressive treatment with high‐dose L‐AmB and timely surgical debridement, the mortality rate remains still high.
Source: Mycoses - Category: Research Authors: Tags: ORIGINAL ARTICLE Source Type: research
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Publication date: Available online 7 November 2018Source: Materials Science and Engineering: CAuthor(s): Antonella Sola, Jessika Bertacchini, Daniele D'Avella, Laura Anselmi, Tullia Maraldi, Sandra Marmiroli, Massimo MessoriAbstractThe need for new approaches to investigate ex vivo the causes and effects of tumor and to achieve improved cancer treatments and medical therapies is particularly urgent for malignant pathologies such as lymphomas and leukemias, whose tissue initiator cells interact with the stroma creating a three-dimensional (3D) protective environment that conventional mono- and bi-dimensional (2D) models are...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In conclusion, GA-A treatment inhibited breast cancer cell viability via JAK2/STAT3 downregulation and may regulate associated targets to serve an anti-MDA-MB-231 role, including mitochondrial apoptosis and regulating the expression of cell-cycle-associated factors. PMID: 30405790 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 9 November 2018Source: Clinica Chimica ActaAuthor(s): Samin Hamidi, Ayda Azami, Elnaz Mehdizadeh-AghdamAbstractMethotrexate (MTX) is an anticancer drug that is widely used in a variety of cancers including primary central nervous system lymphoma. It is also administrated in the treatment of some autoimmune diseases. A simple, accurate, sensitive, and precise mixed hemimicelles dispersive micro-solid phase extraction was proposed for MTX quantification in human urine samples. MTX was quantified by spectrophotometer after dispersive micro-solid phase extraction using ionic liquid functional...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Abstract Methotrexate (MTX) is an anticancer drug that is widely used in a variety of cancers including primary central nervous system lymphoma. It is also administrated in the treatment of some autoimmune diseases. A simple, accurate, sensitive, and precise mixed hemimicelles dispersive micro-solid phase extraction was proposed for MTX quantification in human urine samples. MTX was quantified by spectrophotometer after dispersive micro-solid phase extraction using ionic liquid functionalized magnetic graphene oxide/polypyrrole. Interactions of adsorbent and MTX were modeled by molecular docking and the interactio...
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
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