PCSK9 and resistin: Not only a structural sharing
Chronic inflammation is directly linked to several metabolic diseases, such as atherosclerosis, and obesity, where inflammatory cells infiltrate adipose tissue and release pro-inflammatory mediators, contributing to generate a state of chronic low-grade sub-clinical inflammation. Resistin is an adipokine, secreted primarily by monocytes and macrophages in humans and it interacts with adenylyl cyclase-associated protein 1 (CAP1) receptor, with its carboxy-terminal region, leading to an increase of cAMP intracellular levels and, consequently, to the activation of NF-kB.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: C. Ricci, A. Corsini, M.R. Accomazzo, G. Rovati, M. Camera, L. Rossetti, N. Ferri Source Type: research
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