Genetic variants and animal models in SNCA and Parkinson disease.

Genetic variants and animal models in SNCA and Parkinson disease. Ageing Res Rev. 2014 Apr 21; Authors: Deng H, Yuan L Abstract Parkinson disease (PD; MIM 168600) is the second most common progressive neurodegenerative disorder characterized by a variety of motor and non-motor features. To date, at least 20 loci and 15 disease-causing genes for parkinsonism have been identified. Among them, the α-synuclein (SNCA) gene was associated with PARK1/PARK4. Point mutations, duplications and triplications in the SNCA gene cause a rare dominant form of PD in familial and sporadic PD cases. The α-synuclein protein, a member of the synuclein family, is abundantly expressed in the brain. The protein is the major component of Lewy bodies and Lewy neurites in dopaminergic neurons in PD. Further understanding of its role in the pathogenesis of PD through various genetic techniques and animal models will likely provide new insights into our understanding, therapy and prevention of PD. PMID: 24768741 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research

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Condition:   Parkinson Disease Intervention:   Diagnostic Test: MRI Sponsor:   University of Plymouth Not yet recruiting
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Conditions:   Parkinson Disease;   Parkinsonian Disorders;   Basal Ganglia Diseases;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Movement Disorders;   Neurodegenerative Diseases Intervention:   Device: Verily Study Watch Sponsors:   Radboud University;   UCB Pharma;   Verily Life Sciences LLC Recruiting
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Source: Parkinsons Disease - Category: Neurology Authors: Source Type: research
Contributors : Samantha L Schaffner ; Zinah Wassouf ; Diana F Lazaro ; Mary Xylaki ; Nicole Gladish ; David T Lin ; Julia MacIsaac ; Katia Ramadori ; Julia M Schulze-Hentrich ; Tiago F Outeiro ; Michael S KoborSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensAlthough Parkinson ’s disease (PD) is one of the most rapidly growing neurological disorders, interindividual differences in PD etiology related to genetics are not fully understood. Here, we demonstrate genome-wide DNA methylation and hydroxymethylation alterations associated with overexpression of two PD-linked al pha-synuclein v...
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
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